New insights into biliverdin reductase functions: linking heme metabolism to cell signaling.
نویسنده
چکیده
Biliverdin reductase (BVR) functions in cell signaling through three distinct tracks: a dual-specificity kinase that functions in the insulin receptor/MAPK pathways (25, 29, 51); a bzip-type transcription factor for ATF-2/CREB and HO-1 regulation (1, 25); and a reductase that catalyzes the conversion of biliverdin to bilirubin (27). These, together with the protein's primary and secondary features, intimately link BVR to the entire spectrum of cell-signaling cascades.
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عنوان ژورنال:
- Physiology
دوره 20 شماره
صفحات -
تاریخ انتشار 2005